Agile Small to Medium Batch Production Enabled by XPlanar Technology


How LSS partnered with an international CDMO to remove bottlenecks, accelerate format changes and future proof their production line.
Discover how, together with the customer, we developed one line for multiple packaging patterns – with maximum agility for small to medium batches, fast changeovers, full traceability and readiness for future formats.
 
As the market for pharmaceutical products continues to fragment, CDMOs face increasing pressure to deliver smaller, more diverse batches with shorter lead times while maintaining full regulatory compliance. At the same time, they often do not know who tomorrow’s customer will be or what specific requirements they will need to meet. This makes flexible and easily adaptable solutions essential for remaining competitive.
 
One of Europe’s leading CDMOs approached LSS with a clear challenge: their existing processes for small to medium batch production were too rigid, too manual and too time consuming when performing batch and format changes. They needed a partner who could not only deliver a technical solution but also understand their operational reality and guide them safely into new technological territory. The customer placed considerable trust in LSS to explore a new approach based on Beckhoff’s XPlanar technology—an innovative platform not yet widely used in pharmaceutical packaging.
 
The customer needed a system that was efficient and fully compliant today, yet also capable of scaling with future product pipelines.

Listening First: Understanding the Customer’s Operational Barriers

Through a structured requirements phase, we worked closely with the customer’s production and engineering teams to understand the full scope of their operational challenges:

  • Long changeover times between formats, especially when switching between primary container types
  • Space consuming manual handling activities that carried a risk of human error
  • Increasing demand from global pharma clients for rapid onboarding of new formats
  • Time-consuming batch change and line clearance procedures
  • Increasing need for integrated quality control and digital traceability

During the requirement analysis, we worked closely with the customer to map every packaging format they needed to support. These included foil trays and cartons—both top‑ and side‑loaded—along with the option to place leaflets either at the top or bottom of the pack. 

The same primary product, such as a vial, syringe or pen/auto‑injector, could therefore require multiple packaging combinations such as: 

  • Varying numbers of leaflets 
  • Different cartons and loading directions
  • Glued or tamper‑evident sealing

To support very small batches, the solution also has an integrated manual packing station that maintains full GMP compliance.

This joint exploration of packaging formats gave both parties a clear view of the complexity involved and strengthened confidence that a conventional conveyor based solution would not be sufficient.

Our Solution: A Fully Made-To-Measure XPlanar-Based Platform

This extensive variability in formats was far beyond the capabilities of what one line with traditional transport and handling systems can offer. By contrast, the XPlanar‑based solution allows the customer to define pack formats batch‑by‑batch and adjust the sequence in which components are introduced, ensuring true scalability across current and future requirements.

Together with the customer, we designed and built a highly flexible solution based on Beckhoff’s XPlanar intelligent transport system. The floating movers and tile based modular design enabled us to create a platform that supports dynamic routing, parallel workflows and rapid format reconfiguration – capabilities not possible with traditional conveyor based systems.

The result is a compact (7,5m long), GMP aligned solution engineered specifically for the realities of modern CDMO production, where agility and compliance must go hand in hand.

small batch labelling and packaging for vials, syringes, PFS, Pen injetors and autoinjectors
Five Highlights of the Solution


1 High Operational Efficiency
Independent mover control enables multiple tasks to run in parallel, reducing cycle time per unit and ensuring that no process step becomes a bottleneck.

2. Rapid, fully compliant batch changes
Format and batch changes can be executed in under 30 minutes, including recipe change, documentation workflows and validation relevant steps.

3. Easy and controlled line clearance
A clean mechanical layout and minimised product contact surfaces make line clearance significantly faster and fully compliant with GMP expectations.

4. Fully integrated quality control
Inspection modules, vision systems and data driven quality documentation are integrated into the workflow, ensuring consistent traceability at every step.

5. Seamless introduction of future formats
Thanks to the XPlanar architecture, new formats can easily be introduced – supporting the CDMO’s long term commercial flexibility.

small batch labelling and packaging for pharma productions, CMO and CDMOs
A Production Line Built for Tomorrow’s CDMO Market

The implemented solution enables the customer to run small and medium batches with greatly improved efficiency, while retaining full regulatory control. It supports a scalable portfolio of product formats and gives the CDMO the manufacturing agility needed to remain competitive as client demands continue to evolve.
This project reflects our core mission at LSS: to design and build customer specific, future ready solutions that deliver measurable value in pharmaceutical production – whether for primary packaging, labelling, or specialised small batch operations.

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